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TGF-beta signalling from cell membrane to nucleus through SMAD proteins

被引：3220
作者：
Heldin, CH [1 ]
Miyazono, K [1 ]
tenDijke, P [1 ]
机构：
[1] JAPANESE FDN CANC RES,INST CANC,DEPT BIOCHEM,TOSHIMA KU,TOKYO 170,JAPAN
来源：
NATURE | 1997年 / 390卷 / 6659期
关键词：
D O I：
10.1038/37284
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The recent identification of the SMAD family of signal transducer proteins has unravelled the mechanisms by which transforming growth factor-beta (TGF-beta) signals from the cell membrane to the nucleus. Pathway-restricted SMADs are phosphorylated by specific cell-surface receptors that have serine/threonine kinase activity, then they oligomerize with the common mediator Smad4 and translocate to the nucleus where they direct transcription to effect the cell's response to TGF-beta. Inhibitory SMADs have been identified that block the activation of these pathway-restricted SMADs.
引用
收藏
页码：465 / 471
页数：7
相关论文
共 101 条
  • [41] Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1
    Kretzschmar, M
    Doody, J
    Massague, J
    [J]. NATURE, 1997, 389 (6651) : 618 - 622
  • [42] The TGF-P family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase
    Kretzschmar, M
    Liu, F
    Hata, A
    Doody, J
    Massague, J
    [J]. GENES & DEVELOPMENT, 1997, 11 (08) : 984 - 995
  • [43] Ladher R, 1996, DEVELOPMENT, V122, P2385
  • [44] Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways
    Lagna, G
    Hata, A
    HemmatiBrivanlou, A
    Massague, J
    [J]. NATURE, 1996, 383 (6603) : 832 - 836
  • [45] The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues
    Lawler, S
    Feng, XH
    Chen, RH
    Maruoka, EM
    Turck, CW
    GriswoldPrenner, I
    Derynck, R
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (23) : 14850 - 14859
  • [46] Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1
    Lechleider, RJ
    deCaestecker, MP
    Dehejia, A
    Polymeropoulos, MH
    Roberts, AB
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (30) : 17617 - 17620
  • [47] TRANSFORMING GROWTH-FACTOR-BETA ACTIVATES THE PROMOTER OF CYCLIN-DEPENDENT KINASE INHIBITOR P15(INK4B) THROUGH AN SP1 CONSENSUS SITE
    LI, JM
    NICHOLS, MA
    CHANDRASEKHARAN, S
    XIONG, Y
    WANG, XF
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (45) : 26750 - 26753
  • [48] LIU F, 1995, MOL CELL BIOL, V15, P3479
  • [49] A human Mad protein acting as a BMP-regulated transcriptional activator
    Liu, F
    Hata, A
    Baker, JC
    Doody, J
    Carcamo, J
    Harland, RM
    Massague, J
    [J]. NATURE, 1996, 381 (6583) : 620 - 623
  • [50] LU KX, 1996, EMBO J, V15, P4485
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