Chicoric acid, a new compound able to enhance insulin release and glucose uptake

被引：160

作者：

Tousch, Didier ^{[1
,2
]}

Lajoix, Anne-Dominique ^{[1
,2
]}

Hosy, Eric ^{[3
]}

Azay-Milhau, Jacqueline ^{[1
,2
]}

Ferrare, Karine ^{[1
,2
]}

Jahannault, Celine ^{[1
,2
]}

Cros, Gerard ^{[1
,2
]}

Petit, Pierre ^{[1
,2
]}

机构：

[1] Univ Montpellier I, CPID, CNRS, Fac Pharm,UMR 5232, F-34093 Montpellier 5, France

[2] CHRU St Eloi, F-34295 Montpellier 5, France

[3] Univ Grenoble 1, CNRS, CEA, Inst Biol Struct,UMR5075, Grenoble, France

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 377卷 / 01期

关键词：

Diabetes; chicoric acid; Chlorogenic acid; Insulin secretion; Glucose uptake; Electrophysiology;

D O I：

10.1016/j.bbrc.2008.09.088

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Caffeic acid and chlorogenic acid (CGA), a mono-caffeoyl ester, have been described as potential antidiabetic agents. Using in vitro studies, we report the effects of a dicaffeoyl ester. Chicoric acid (CRA) purified from Cichorium intybus, on glucose uptake insulin secretion. Our results show that CRA and CGA increased glucose uptake in L6 muscular cells, an effect only observed in the presence of stimulating concentrations of insulin. Moreover, we found that both CRA and CGA were able to stimulate insulin secretion from the INS-1 E insulin-secreting cell line and rat islets of Langerhans. In the later case, the effect of CPA is only observed in the presence of subnormal glucose levels. PatCh clamps studies show that the mechanism of CRA and CGA was different from that of sulfonylureas, as they did not close K-ATP channels. Chicoric acid is a new potential antidiabetic agent carrying both insulin sensitizing and insulin-secreting properties. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：131 / 135

页数：5

共 24 条

[21]

Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes [J].