Undetectable levels of CSF hypocretin-1 (orexin-A) in two prepubertal boys with narcolepsy

被引：17

作者：

Tsukamoto, H

Ishikawa, T

Fujii, Y

Fukumizu, M

Sugai, K

Kanbayashi, T

机构：

[1] Nagoya City Univ, Sch Med, Dept Pediat, Mizuho Ku, Nagoya, Aichi 4678601, Japan

[2] Natl Ctr Hosp Mental Nervous & Muscular Disorders, Natl Ctr Neurol & Psychiat, Dept Pediat Neurol, Kodaira, Tokyo, Japan

[3] Akita Univ, Sch Med, Dept Neuropsychiat, Akita 010, Japan

来源：

NEUROPEDIATRICS | 2002年 / 33卷 / 01期

关键词：

narcolepsy; cataplexy; hypocretin (orexin); human leukocyte antigen; child; sleep disorder;

D O I：

10.1055/s-2002-23601

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report on two prepubertal narcoleptic boys with undetectable levels of hypocretin-1 (orexin-A) in their cerebrospinal fluid (CSF). The disease onset times were 6 and 8 years, and CSF was collected 8 and 20 months after the onset, respectively. The initial symptoms were excessive daytime sleepiness, cataplexy and disrupted nocturnal sleep. Both subjects are DRB1*1501 and DQB1*0602 positive. The measurement of CSF hypocretin-1 is valuable for the decisive diagnosis of narcolepsy and for selecting the type of treatment in prepubertal children. Our results suggest that a significant degree of hypocretin deficiency is already present at the disease onset.

引用

页码：51 / 52

页数：2

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