Neurobehavioral effects of vanadium

被引：31

作者：

Barth, A ^{[1
]}

Schaffer, AW ^{[1
]}

Konnaris, C ^{[1
]}

Blauensteiner, R ^{[1
]}

Winker, R ^{[1
]}

Osterode, W ^{[1
]}

Rüdiger, HW ^{[1
]}

机构：

[1] Univ Vienna, Div Occupat Med, A-1090 Vienna, Austria

来源：

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A | 2002年 / 65卷 / 09期

关键词：

D O I：

10.1080/15287390252900377

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

It was our aim to study whether chronic exposure to vanadium reduces cognitive abilities. We investigated effects on attention, visuospatial and visuomotor functioning, reaction time, short-term memory, and prefrontal functioning. Forty-nine vanadium exposed subjects with a mean vanadium level in urine (VanU) of 14.4 mu/L and 49 controls ( VanU: 0.8 mug/L) with the same socioeconomic background were investigated. Neuropsychological tests were done using a modified Wisconsin Card Sorting Test (WCST), Block Design Test (BDT), Visual Recognition Test (VRT), Simple Reaction Time (SRT), Choice Reaction (CR), Digit Symbol Substitution (DSS), and Digit Span (DS). Exposure was assessed by using the vanadium level in urine and serum. While there were significant differences in BDT and DSS, no differences were found in WCST, SRT, CR, and DS. Significant correlations existed between the vanadium levels in urine and serum and the cognitive deficits. Vanadium concentrations around 14.2 mug/L in urine reduce neurobehavioral abilities, particularly visuospatial abilities and attention.

引用

页码：677 / 683

页数：7

共 16 条

[11]

NAYLOR GJ, 1984, BIOL PSYCHIAT, V19, P759

[12] MODIFIED CARD SORTING TEST SENSITIVE TO FRONTAL LOBE DEFECTS [J].