V-SRC'S hold over actin and cell adhesions

被引：262

作者：

Frame, MC

Fincham, VJ

Carragher, NO

Wyke, JA

机构：

[1] Univ Glasgow, Beatson Inst Canc Res, Canc Res UK Beatson Labs, Glasgow G61 1BD, Lanark, Scotland

[2] Univ Glasgow, Inst Biomed & Life Sci, Canc Res UK Beatson Labs, Glasgow G61 1BD, Lanark, Scotland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 04期

关键词：

D O I：

10.1038/nrm779

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The oncoprotein v-Src and its cellular homologue (c-Src) are tyrosine kinases that modulate the actin cytoskeleton and cell adhesions. Through the concerted action of their protein-interaction and kinase domains, they are targeted to cell-matrix integrin adhesions or cadherin-dependent junctions between epithelial cells, where they phosphorylate substrates that induce adhesion turnover and actin re-modelling. Recent experiments have defined some of the key targets and effector pathways that mediate the pleiotropic oncogenic effects of v-Src.

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收藏

页码：233 / 245

页数：13

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