ClusterMine360: a database of microbial PKS/NRPS biosynthesis

被引：94

作者：

Conway, Kyle R. ^{[1
]}

Boddy, Christopher N. ^{[1
,2
]}

机构：

[1] Univ Ottawa, Dept Chem, Ctr Adv Res Environm Genom, Ottawa, ON K1N 6N5, Canada

[2] Univ Ottawa, Dept Biol, Ctr Adv Res Environm Genom, Ottawa, ON K1N 6N5, Canada

来源：

NUCLEIC ACIDS RESEARCH | 2013年 / 41卷 / D1期

基金：

加拿大自然科学与工程研究理事会;

关键词：

SORANGIUM-CELLULOSUM; GENE-CLUSTER; SEQUENCE; EPOTHILONES; ANNOTATION; PUBCHEM; SYSTEM;

D O I：

10.1093/nar/gks993

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ClusterMine360 (http://www.clustermine360.ca/) is a database of microbial polyketide and non-ribosomal peptide gene clusters. It takes advantage of crowd-sourcing by allowing members of the community to make contributions while automation is used to help achieve high data consistency and quality. The database currently has > 200 gene clusters from > 185 compound families. It also features a unique sequence repository containing > 10 000 polyketide synthase/non-ribosomal peptide synthetase domains. The sequences are filterable and downloadable as individual or multiple sequence FASTA files. We are confident that this database will be a useful resource for members of the polyketide synthases/non-ribosomal peptide synthetases research community, enabling them to keep up with the growing number of sequenced gene clusters and rapidly mine these clusters for functional information.

引用

页码：D402 / D407

页数：6

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