Thrombopoietin levels increased in patients with severe acute respiratory syndrome

被引：35

作者：

Yang, Mo ^{[1
]}

Ng, Margaret H. L. ^{[3
]}

Li, Chi Kong ^{[4
]}

Chan, Paul K. S. ^{[5
]}

Liu, Chang ^{[2
]}

Ye, Jie Yu ^{[1
]}

Chong, Beng H. ^{[6
]}

机构：

[1] Univ Hong Kong, Li Ka Shing Fac Med, Dept Paediat & Adolescent Med, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Li Ka Shing Fac Med, Mol Chinese Med Lab, Hong Kong, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China

[4] Chinese Univ Hong Kong, Dept Paediat, Hong Kong, Hong Kong, Peoples R China

[5] Chinese Univ Hong Kong, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China

[6] Univ New S Wales, St George Clin Sch, Dept Med, Sydney, NSW 2052, Australia

来源：

THROMBOSIS RESEARCH | 2008年 / 122卷 / 04期

关键词：

thrombopoietin; CFU-MK; SARS-CoV; CD34+cells; megakaryocytes;

D O I：

10.1016/j.thromres.2007.12.021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hematological changes in patients with Severe Acute Respiratory Syndrome (SARS) are common and frequently include thrombocytopenia. Using a ELISA method, we found an increase in thrombopoietin (TPO) levels in the plasma of convalesced SARS patients (290 +/- 53 pg/ml) and active SARS patients (251 +/- 23 pg/ml) comparing to that from normal control patients (228 +/- 17 pg/ml). In addition, the plasma from active SARS patients had an inhibitory effect on CFU-MK formation, which could be neutralized by anti-TGF-beta antibodies. In the experiment to determine whether SARS-CoV can directly infect hematopoietic stem cells and megakaryocytic cells, incubation of the cells with SARS-CoV did not show active infection. Our findings of increased TPO levels in the plasma of SARS patients provide a possible explanation for the genesis of thrombocytosis, which frequently develops from thrombocytopenia in SARS patients. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：473 / 477

页数：5

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