Cell cycle - Fools rush in

被引：43

作者：

Piwnica-Worms, H ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Cell Biol & Physiol, St Louis, MO 63110 USA

来源：

NATURE | 1999年 / 401卷 / 6753期

关键词：

D O I：

10.1038/44029

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When a dividing cell's DNA is damaged, that cell needs to stop dividing so that the damage can be repaired. There are two main points at which the cell-division cycle can be halted. A study of one of these -- the G2 DNA-damage checkpoint -- shows that there are two parts to checkpoint control. The first, checkpoint initiation, does not seem to depend on the tumour-suppressor protein p53. But maintenance of this checkpoint, it seems, does.

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页码：535 / +

页数：2

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