Effect of small scale culture vessel type on hyphal fragment size and erythromycin production in Saccharopolyspora erythraea

被引：20

作者：

Bushell, ME

Dunstan, GL

Wilson, GC

机构：

[1] Microbial Products Laboratory, School of Biological Sciences, University of Surrey, Guildford, Surrey

来源：

BIOTECHNOLOGY LETTERS | 1997年 / 19卷 / 09期

关键词：

D O I：

10.1023/A:1018325301500

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Erythromycin production dynamics in stirred, baffled shaken and non-baffled shaken flasks was strongly correlated with the different distributions of hyphal particle diameters observed. Production only took place when hyphal fragments with diameters greater than 88 mu m were observed. Results are consistent with significant hyphal breakage rates, even in non-baffled shaken flasks.

引用

页码：849 / 852

页数：4