A role for β-melanocyte-stimulating hormone in human body-weight regulation

被引：138

作者：

Biebermann, H

Castañeda, TR

van Landeghem, F

von Deimling, A

Escher, F

Brabant, G

Hebebrand, J

Hinney, A

Tschöp, MH

Grüters, A

Krude, H ^{[1
]}

机构：

[1] Univ Med Berlin, Charite, Inst Pediat Endocrinol, D-13353 Berlin, Germany

[2] Univ Cincinnati, Dept Psychiat, Obes Res Ctr, Cincinnati, OH 45237 USA

[3] German Inst Human Nutr, Dept Pharmacol, D-14558 Nuthetal, Germany

[4] Univ Med Berlin, Charite, Inst Neuropathol, D-13353 Berlin, Germany

[5] Hannover Med Sch, Dept Endocrinol, D-30625 Hannover, Germany

[6] Univ Duisburg Essen, Dept Child & Adolescent Psychiat, Rhein Kliniken Essen, D-45122 Essen, Germany

来源：

CELL METABOLISM | 2006年 / 3卷 / 02期

关键词：

D O I：

10.1016/j.cmet.2006.01.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pro-opiomelanocortin (POMC) expressing neurons mediate the regulation of orexigenic drive by peripheral hormones such as leptin, cholecystokinin, ghrelin, and insulin. Most research effort has focused on alpha-melanocyte-stimulating hormone (alpha-MSH) as the predominant POMC-derived neuropeptide in the central regulation of human energy balance and body weight. Here we report a missense mutation within the coding region of the POMC-derived peptide beta-MSH (Y5C-beta-MSH) and its association with early-onset human obesity. In vitro and in vivo data as well as postmortem human brain studies indicate that the POMC-derived neuropeptide beta-MSH plays a critical role in the hypothalamic control of body weight in humans.

引用

收藏

页码：141 / 146

页数：6

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