Selective estrogen receptor modulation: Concept and consequences in cancer

被引：260

作者：

Jordan, VC ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

来源：

CANCER CELL | 2004年 / 5卷 / 03期

关键词：

D O I：

10.1016/S1535-6108(04)00059-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Extended exposure to the selective estrogen receptor modulators (SERMs) such as raloxifene to prevent osteoporosis and tamoxifen or the aromatase inhibitors to treat or prevent breast cancer are established therapeutic strategies. However, there are now clearly defined consequences of exhaustive antihormonal therapy in breast cancer. Ultimately, drug resistance to SERMs and aromatase inhibitors enhances cancer cell survival but a paradoxical supersensitivity to estrogen action develops that causes cancer cell apoptosis. The future exploitation of these novel data will allow selective killing of cancer with fewer side effects for patients.

引用

页码：207 / 213

页数：7

共 56 条

[1]

Baum M, 2002, LANCET, V359, P2131

[2] Molecular basis of agonism and antagonism in the oestrogen receptor [J].

Brzozowski, AM ;

Pike, ACW ;

Dauter, Z ;

Hubbard, RE ;

Bonn, T ;

Engstrom, O ;

Ohman, L ;

Greene, GL ;

Gustafsson, JA ;

Carlquist, M .

NATURE, 1997, 389 (6652) :753-758

[3]

Chisamore MJ, 2001, CLIN CANCER RES, V7, P3156

[4] Influence of estrogen plus progestin on breast, cancer and mammography in healthy postmenopausal women - The Women's Health Initiative Randomized trial [J].

Chlebowski, RT ;

Hendrix, SL ;

Langer, RD ;

Stefanick, ML ;

Gass, M ;

Lane, D ;

Rodabough, RJ ;

Gilligan, MA ;

Cyr, MG ;

Thomson, CA ;

Khandekar, J ;

Petrovitch, H ;

McTiernan, A .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (24) :3243-3253

[5]

Clarke M, 1998, LANCET, V351, P1451

[6] The effect of raloxifene on risk of breast cancer in postmenopausal women - Results from the MORE randomized trial [J].

Cummings, SR ;

Eckert, S ;

Krueger, KA ;

Grady, D ;

Powles, TJ ;

Cauley, JA ;

Norton, L ;

Nickelsen, T ;

Bjarnason, NH ;

Morrow, M ;

Lippman, ME ;

Black, D ;

Glusman, JE ;

Costa, A ;

Jordan, VC .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (23) :2189-2197

[7] AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor [J].

de Mora, JF ;

Brown, M .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (14) :5041-5047

[8] Oestrogen receptors -: an overview [J].

Enmark, E ;

Gustafsson, JÅ .

JOURNAL OF INTERNAL MEDICINE, 1999, 246 (02) :133-138

[9] Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene -: Results from a 3-year randomized clinical trial [J].

Ettinger, B ;

Black, DM ;

Mitlak, BH ;

Knickerbocker, RK ;

Nickelsen, T ;

Genant, HK ;

Christiansen, C ;

Delmas, PD ;

Zanchetta, JR ;

Stakkestad, J ;

Glüer, CC ;

Krueger, K ;

Cohen, FJ ;

Eckert, S ;

Ensrud, KE ;

Avioli, LV ;

Lips, P ;

Cummings, SR .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (07) :637-645

[10] Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 study [J].

Fisher, B ;

Costantino, JP ;

Wickerham, DL ;

Redmond, CK ;

Kavanah, M ;

Cronin, WM ;

Vogel, V ;

Robidoux, A ;

Dimitrov, N ;

Atkins, J ;

Daly, M ;

Wieand, S ;

Tan-Chiu, E ;

Ford, L ;

Wolmark, N .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (18) :1371-1388

← 1 2 3 4 5 6 →