CUTting genetic noise by polyadenylation-induced RNA degradation

被引：8

作者：

Chanfreau, GF ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA

来源：

TRENDS IN CELL BIOLOGY | 2005年 / 15卷 / 12期

关键词：

D O I：

10.1016/j.tcb.2005.10.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Silencing of genomic regions in eukaryotes is thought to be the result of transcriptional repression. Recent results show that nuclear RNA degradation plays a major role in discarding RNA molecules with no obvious roles that are produced by cryptic RNA polymerase II transcription throughout the Saccharomyces cerevisiae genome. These cryptic transcripts are polyadenylated at their 3'-end by a poly(A) polymerase complex distinct from that used by the mRNA factory, which serves to tag these aberrant transcripts for nuclear degradation.

引用

页码：635 / 637

页数：3

共 11 条

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