Association of BMI with the β3-adrenergic receptor gene polymorphism in Japanese:: Meta-analysis

被引：77

作者：

Kurokawa, N ^{[1
]}

Nakai, K ^{[1
]}

Kameo, S ^{[1
]}

Liu, ZM ^{[1
]}

Satoh, H ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Environm Hlth Sci, Aoba Ku, Sendai, Miyagi 9808575, Japan

来源：

OBESITY RESEARCH | 2001年 / 9卷 / 12期

关键词：

extension of ANOVA; population size; allele frequency;

D O I：

10.1038/oby.2001.102

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To assess the effect of the Trp64Arg polymorphism in the beta3-adrenergic receptor gene (ADRB3) on body mass index (BMI) in the Japanese population. Research Methods and Procedures: We selected studies that evaluated the association between BMI and ADRB3 polymorphism among Japanese, using MEDLINE and PubMed. After data collection, an extension of ANOVA was performed to assess the differences according to the genotype. Results: In a total of 35 subgroups including 2316 subjects with the Trp64Arg variant and 4266 subjects without this variant, the weighted mean difference in BMI was 0.26 kg/m(2) (95% confidence interval: 0.18 to 0.42; p < 0.01), indicating that variant carriers exhibited higher BMI than did normal homozygous subjects. Discussion: Although it is known that the allele frequency of the ADRB3 polymorphism differs among races, this study focuses on the Japanese population, which has a high allele frequency of ADRB3 polymorphism. We assumed that statistical errors would be prevented due to the sufficient number of subjects. In conclusion. the results support the hypothesis that ADRB3 gene polymorphism is associated with BMI.

引用

页码：741 / 745

页数：5