One-step reductive amidation of nitro arenes:: application in the synthesis of Acetaminophen™

被引：47

作者：

Bhattacharya, A ^{[1
]}

Purohit, VC

Suarez, V

Tichkule, R

Parmer, G

Rinaldi, F

机构：

[1] Texas A&M Univ, Dept Chem, Kingsville, TX 78363 USA

[2] Bristol Myers Squibb Co, Dept Proc Res, Pharmaceut Res Inst, New Brunswick, NJ 08903 USA

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.tetlet.2005.09.196

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel thioacetate mediated one-step reductive acetamidation of aryl nitro compounds was developed and applied to an efficient synthesis of acetaminophen. The reaction also proceeds well without a solvent in the presence of a catalytic amount of surfactant. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1861 / 1864

页数：4

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