The effects of 1α,25-dihydroxyvitamin D3 on matrix metalloproteinase and prostaglandin E2 production by cells of the rheumatoid lesion

被引：56

作者：

Tetlow, Lynne C. ^{[1
]}

Woolley, David E. ^{[1
]}

机构：

[1] Manchester Royal Infirm, Univ Dept Med, Manchester M13 9WL, Lancs, England

来源：

ARTHRITIS RESEARCH | 1999年 / 1卷 / 01期

关键词：

1; alpha; 25-dihydroxyvitamin D-3; matrix metalloproteinase; prostaglandin E-2; rheumatoid arthritis;

D O I：

10.1186/ar12

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The biologically active metabolite of vitamin D-3, 1 alpha,25-dihydroxyvitamin D-3 [1 alpha,25(OH)(2)D-3], acts through vitamin D receptors, which were found in rheumatoid tissues in the present study. IL-1 beta-activated rheumatoid synovial fibroblasts and human articular chondrocytes were shown to respond differently to exposure to 1 alpha,25(OH)(2)D-3, which has different effects on the regulatory pathways of specific matrix metalloproteinases and prostaglandin E-2.

引用

页码：63 / 70

页数：8

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