The effects of 1α,25-dihydroxyvitamin D3 on matrix metalloproteinase and prostaglandin E2 production by cells of the rheumatoid lesion

被引：56

作者：

Tetlow, Lynne C. ^{[1
]}

Woolley, David E. ^{[1
]}

机构：

[1] Manchester Royal Infirm, Univ Dept Med, Manchester M13 9WL, Lancs, England

来源：

ARTHRITIS RESEARCH | 1999年 / 1卷 / 01期

关键词：

1; alpha; 25-dihydroxyvitamin D-3; matrix metalloproteinase; prostaglandin E-2; rheumatoid arthritis;

D O I：

10.1186/ar12

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The biologically active metabolite of vitamin D-3, 1 alpha,25-dihydroxyvitamin D-3 [1 alpha,25(OH)(2)D-3], acts through vitamin D receptors, which were found in rheumatoid tissues in the present study. IL-1 beta-activated rheumatoid synovial fibroblasts and human articular chondrocytes were shown to respond differently to exposure to 1 alpha,25(OH)(2)D-3, which has different effects on the regulatory pathways of specific matrix metalloproteinases and prostaglandin E-2.

引用

页码：63 / 70

页数：8

共 25 条

[11] IMMUNOMODULATORY ROLE OF 1,25-DIHYDROXYVITAMIN-D3 [J].

LEMIRE, JM .

JOURNAL OF CELLULAR BIOCHEMISTRY, 1992, 49 (01) :26-31

[12]

MAWER EB, 1991, J BONE MINER RES, V6, P733

[13] HUMAN SYNOVIUM RELEASES A FACTOR WHICH STIMULATES CHONDROCYTE PRODUCTION OF PGE AND PLASMINOGEN-ACTIVATOR [J].

MEATS, JE ;

MCGUIRE, MB ;

RUSSELL, RGG .

NATURE, 1980, 286 (5776) :891-892

[14] THE VITAMIN-D ENDOCRINE SYSTEM - STEROID-METABOLISM, HORMONE RECEPTORS, AND BIOLOGICAL RESPONSE (CALCIUM-BINDING PROTEINS) [J].

NORMAN, AW ;

ROTH, J ;

ORCI, L .

ENDOCRINE REVIEWS, 1982, 3 (04) :331-366

[15] IMMUNOLOCALIZATION OF MATRIX METALLOPROTEINASE-3 (STROMELYSIN) IN RHEUMATOID SYNOVIOBLASTS (B-CELLS) - CORRELATION WITH RHEUMATOID-ARTHRITIS [J].

OKADA, Y ;

TAKEUCHI, N ;

TOMITA, K ;

NAKANISHI, I ;

NAGASE, H .

ANNALS OF THE RHEUMATIC DISEASES, 1989, 48 (08) :645-653

[16] MATRIX METALLOPROTEINASE-2 FROM HUMAN RHEUMATOID SYNOVIAL FIBROBLASTS - PURIFICATION AND ACTIVATION OF THE PRECURSOR AND ENZYMATIC-PROPERTIES [J].

OKADA, Y ;

MORODOMI, T ;

ENGHILD, JJ ;

SUZUKI, K ;

YASUI, A ;

NAKANISHI, I ;

SALVESEN, G ;

NAGASE, H .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 194 (03) :721-730

[17]

SUDA T, 1989, P SOC EXP BIOL MED, V191, P214

[18] Effects of induced mast cell activation on prostaglandin E and metalloproteinase production by rheumatoid synovial tissue in vitro [J].

Tetlow, LC ;

Harper, N ;

Dunningham, T ;

Morris, MA ;

Bertfield, H ;

Woolley, DE .

ANNALS OF THE RHEUMATIC DISEASES, 1998, 57 (01) :25-32

[19]

TETLOW LC, 1995, VIRCHOWS ARCH, V425, P569

[20]

Tetlow LC, 1998, BRIT J RHEUMATOL, V37, P64

← 1 2 3 →