A Bio-inspired Copper Catalyst System for Practical Catalytic Cyanation of Aryl Bromides

被引：60

作者：

Schareina, Thomas ^{[1
]}

Zapf, Alexander ^{[1
]}

Cotte, Alain ^{[2
]}

Mueller, Nikolaus ^{[2
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

[2] Saltigo GmbH, D-51369 Leverkusen, Germany

来源：

SYNTHESIS-STUTTGART | 2008年 / 20卷 / 20期

关键词：

copper(I); cyanation; alkylimidazoles; bromoarenes; nitriles;

D O I：

10.1055/s-0028-1083161

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and environmentally improved protocol for the cyanation of aryl halides with the nontoxic cyanide source potassium hexacyanoferrate(II) {K-4[Fe(CN)(6)]} using copper catalysis and a ligand system based on 1-alkyl-1H-imidazoles is presented. The advantages of this system are a wide substrate range, high selectivity, easy handling, and inexpensive reagents.

引用

页码：3351 / 3355

页数：5

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