Interleukin-12 induces a Th1-like response to Burkholderia mallei and limited protection in BALB/c mice

被引：32

作者：

Amemiya, K ^{[1
]}

Meyers, JL ^{[1
]}

Trevino, SR ^{[1
]}

Chanh, TC ^{[1
]}

Norris, SL ^{[1
]}

Waag, DM ^{[1
]}

机构：

[1] USA, Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA

来源：

VACCINE | 2006年 / 24卷 / 09期

关键词：

IL-12; Th1; response; limited protection;

D O I：

10.1016/j.vaccine.2005.09.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated the effect of interleukin (IL)-12 on the immune response to Burkholderia mallei in BALB/c mice. Mice were vaccinated with non-viable B. mallei cells with or without IL-12. There was a seven- to nine-fold increase in IgG2a levels, and a significant increase in the proliferative response and interferon (IFN)-gamma production by splenocytes from mice that received B. mallei and IL-12. We saw an increase in survivors in the groups of mice that received B. mallei and IL-12 when challenged, compared to mice that received only B. mallei or IL-12. The results Suggest that IL-12 can enhance the Th1-like immune response to B. mallei and mediate limited protection from a lethal challenge. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1413 / 1420

页数：8

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