学术探索
学术期刊
新闻热点
数据分析
智能评审

NFAT signaling: Choreographing the social lives of cells

被引：1085
作者：
Crabtree, GR [1 ]
Olson, EN
机构：
[1] Stanford Univ, Howard Hughes Med Inst, Dept Dev Biol, Stanford, CA 94305 USA
[2] Stanford Univ, Howard Hughes Med Inst, Dept Pathol, Stanford, CA 94305 USA
[3] Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA
来源：
CELL | 2002年 / 109卷
关键词：
D O I：
10.1016/S0092-8674(02)00699-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc proteins into the nucleus, where they cooperate with other proteins to form complexes on DNA. Nuclear import is opposed by kinases such as GSK3, thereby rendering transcription continuously responsive to receptor occupancy. Disruptions of the genes involved in NFAT signaling are implicating this pathway as a regulator of developmental cell-cell interactions.
引用
收藏
页码：S67 / S79
页数：13
相关论文
共 98 条
  • [1] Activation and cellular localization of the cyclosporine A-sensitive transcription factor NF-AT in skeletal muscle cells
    Abbott, KL
    Friday, BB
    Thaloor, D
    Murphy, TJ
    Pavlath, GK
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (10) : 2905 - 2916
  • [2] Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo
    Antos, CL
    McKinsey, TA
    Frey, N
    Kutschke, W
    McAnally, J
    Shelton, JM
    Richardson, JA
    Hill, JA
    Olson, EN
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) : 907 - 912
  • [3] Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A
    Aramburu, J
    Yaffe, MB
    López-Rodríguez, C
    Cantley, LC
    Hogan, PG
    Rao, A
    [J]. SCIENCE, 1999, 285 (5436) : 2129 - 2133
  • [4] CALCINEURIN ACTIVITY IS ONLY PARTIALLY INHIBITED IN LEUKOCYTES OF CYCLOSPORINE-TREATED PATIENTS
    BATIUK, TD
    PAZDERKA, F
    HALLORAN, PF
    [J]. TRANSPLANTATION, 1995, 59 (10) : 1400 - 1404
  • [5] Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
    Beals, CR
    Sheridan, CM
    Turck, CW
    Gardner, P
    Crabtree, GR
    [J]. SCIENCE, 1997, 275 (5308) : 1930 - 1933
  • [6] Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction
    Beals, CR
    Clipstone, NA
    Ho, SN
    Crabtree, GR
    [J]. GENES & DEVELOPMENT, 1997, 11 (07) : 824 - 834
  • [7] Calcium - a life and death signal
    Berridge, MJ
    Bootman, MD
    Lipp, P
    [J]. NATURE, 1998, 395 (6703) : 645 - 648
  • [8] Ca2+-dependent gene expression mediated by MEF2 transcription factors
    Blaeser, F
    Ho, N
    Prywes, R
    Chatila, TA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (01) : 197 - 209
  • [9] Calvo S, 1999, MOL CELL BIOL, V19, P515
  • [10] Structure of the DNA binding domains from NFAT, Fos and Jun bound specifically to DNA
    Chen, L
    Glover, JNM
    Hogan, PG
    Rao, A
    Harrison, SC
    [J]. NATURE, 1998, 392 (6671) : 42 - 48
12345678910