NFAT signaling: Choreographing the social lives of cells

被引：1085

作者：

Crabtree, GR ^{[1
]}

Olson, EN

机构：

[1] Stanford Univ, Howard Hughes Med Inst, Dept Dev Biol, Stanford, CA 94305 USA

[2] Stanford Univ, Howard Hughes Med Inst, Dept Pathol, Stanford, CA 94305 USA

[3] Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA

来源：

CELL | 2002年 / 109卷

关键词：

D O I：

10.1016/S0092-8674(02)00699-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc proteins into the nucleus, where they cooperate with other proteins to form complexes on DNA. Nuclear import is opposed by kinases such as GSK3, thereby rendering transcription continuously responsive to receptor occupancy. Disruptions of the genes involved in NFAT signaling are implicating this pathway as a regulator of developmental cell-cell interactions.

引用

页码：S67 / S79

页数：13

共 98 条

[81] Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression [J].

Timmerman, LA ;

Clipstone, NA ;

Ho, SN ;

Northrop, JP ;

Crabtree, GR .

NATURE, 1996, 383 (6603) :837-840

[82]

VERWEIJ CL, 1990, J BIOL CHEM, V265, P15788

[83] Regulation of IL-4 production in mast cells: a paradigm for cell-type-specific gene expression [J].

Weiss, DL ;

Brown, MA .

IMMUNOLOGICAL REVIEWS, 2001, 179 :35-47

[84] Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc [J].

Wolfe, SA ;

Zhou, P ;

Dotsch, V ;

Chen, L ;

You, A ;

Ho, SN ;

Crabtree, GR ;

Wagner, G ;

Verdine, GL .

NATURE, 1997, 385 (6612) :172-176

[85] P21(RAS) AND CALCINEURIN SYNERGIZE TO REGULATE THE NUCLEAR FACTOR OF ACTIVATED T-CELLS [J].

WOODROW, M ;

CLIPSTONE, NA ;

CANTRELL, D .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (05) :1517-1522

[86] Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway [J].

Wu, H ;

Rothermel, B ;

Kanatous, S ;

Rosenberg, P ;

Naya, FJ ;

Shelton, JM ;

Hutcheson, KA ;

DiMaio, JM ;

Olson, EN ;

Bassel-Duby, R ;

Williams, RS .

EMBO JOURNAL, 2001, 20 (22) :6414-6423

[87] MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type [J].

Wu, H ;

Naya, FJ ;

McKinsey, TA ;

Mercer, B ;

Shelton, JM ;

Chin, ER ;

Simard, AR ;

Michel, RN ;

Bassel-Duby, R ;

Olson, EN ;

Williams, RS .

EMBO JOURNAL, 2000, 19 (09) :1963-1973

[88] An enhanced immune response in mice lacking the transcription factor NFAT1 [J].

Xanthoudakis, S ;

Viola, JPB ;

Shaw, KTY ;

Luo, C ;

Wallace, JD ;

Bozza, PT ;

Curran, T ;

Rao, A .

SCIENCE, 1996, 272 (5263) :892-895

[89] Vascular-specific growth factors and blood vessel formation [J].

Yancopoulos, GD ;

Davis, S ;

Gale, NW ;

Rudge, JS ;

Wiegand, SJ ;

Holash, J .

NATURE, 2000, 407 (6801) :242-248

[90] Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles [J].

Yang, J ;

Rothermel, B ;

Vega, RB ;

Frey, N ;

McKinsey, TA ;

Olson, EN ;

Bassel-Duby, R ;

Williams, RS .

CIRCULATION RESEARCH, 2000, 87 (12) :E61-E68

← 1 2 3 4 5 6 7 8 9 10 →