Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues

被引：97

作者：

Liu, Huijuan ^{[1
]}

Xia, Xuechun ^{[1
]}

Li, Baojie ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Minist Educ, Key Lab Genet Dev & Neuropsychiat Disorders, Bio X Inst, Shanghai 200240, Peoples R China

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2015年 / 240卷 / 08期

关键词：

Mesenchymal stem cells; hematopoietic stem cell; niche; aging; biased differentiation; bone remodeling; osteoporosis; BONE-MARROW NICHE; DIFFERENTIATION FACTOR 11; DNA-DAMAGE RESPONSE; AGE-RELATED-CHANGES; OSTEOBLAST DIFFERENTIATION; STROMAL CELLS; IN-VITRO; INCREASED ADIPOGENESIS; TELOMERE DYSFUNCTION; PROGENITOR CELLS;

D O I：

10.1177/1535370215591828

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The aging population and the incidence of aging-related diseases such as osteoporosis are on the rise. Aging at the tissue and organ levels usually involves tissue stem cells. Human and animal model studies indicate that aging affects two aspects of mesenchymal stem cell (MSC): a decrease in the bone marrow MSC pool and biased differentiation into adipocyte at the cost of osteoblast, which underlie the etiology of osteoporosis. Aging of MSC cells is also detrimental to some non-skeletal tissues, in particular the hematopoietic system, where MSCs serve as a niche component. In addition, aging compromises the therapeutic potentials of MSC cells, including cells isolated from aged individuals or cells cultured for many passages. Here we discuss the recent progress on our understanding of MSC aging, with a focus on the effects of MSC aging on bone remodeling and hematopoiesis and the mechanisms of MSC aging.

引用

页码：1099 / 1106

页数：8

共 99 条

[1]

Obesity-driven disruption of haematopoiesis and the bone marrow niche [J].