RNase domains determine the functional difference between IRE1α and IRE1β

被引：64

作者：

Imagawa, Yusuke ^{[1
]}

Hosoda, Akira ^{[1
,2
]}

Sasaka, Shin-ichi ^{[1
]}

Tsuru, Akio ^{[1
]}

Kohno, Kenji ^{[1
]}

机构：

[1] Nara Inst Sci & Technol, Grad Sch Biol Sci, Ikoma 6300192, Japan

[2] RIKEN, Iwawaki Initiat Res Unit, Wako, Saitama 3510198, Japan

来源：

FEBS LETTERS | 2008年 / 582卷 / 05期

关键词：

ER stress; IRE1; unfolded protein response;

D O I：

10.1016/j.febslet.2008.01.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endoplasmic reticulum (ER) stress is associated with the functional disorder of the ER. During conditions of ER stress, cells induce at least two responses to maintain ER function: transcriptional upregulation of ER quality control genes, and translational attenuation of protein synthesis. Induction of ER quality control proteins is mediated by IRE1 alpha, which activates the transcription factor XBP1 via an unconventional splicing event, while a partial translational attenuation is mediated by IRE1 beta. Here, we show by both in vivo and in vitro analyses that the RNase domain of IRE1 determines the functional specificities of each of these isoforms. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：656 / 660

页数：5

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