Unraveling the NALP-3/IL-1β inflammasome:: A big lesson from a small mutation

被引：45

作者：

Dinarello, CA ^{[1
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Div Infect Dis, Denver, CO 80262 USA

来源：

IMMUNITY | 2004年 / 20卷 / 03期

关键词：

D O I：

10.1016/S1074-7613(04)00055-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytokine-mediated inflammation is a target for novel therapies as well as for fundamental research. A single amino acid mutation in the NALP-3 gene controlling the activation of caspase-1 results in increased processing of the inactive IL-1beta precursor and release of the active cytokine. Blocking IL-1 receptors arrests inflammation in humans with the mutation.

引用

页码：243 / 244

页数：2

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