Cytokine loops driving senescence

被引：44

作者：

Bartek, Jiri ^{[1
,2
]}

Hodny, Zdenek ^{[1
,2
]}

Lukas, Jiri ^{[1
,2
]}

机构：

[1] Danish Canc Soc, Canc Biol & Ctr Genotox Stress Res, Inst Canc Biol, Copenhagen, Denmark

[2] Acad Sci Czech Republ, Inst Mol Genet, Lab Genome Integr, Prague, Czech Republic

来源：

NATURE CELL BIOLOGY | 2008年 / 10卷 / 08期

关键词：

D O I：

10.1038/ncb0808-887

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cellular senescence, the permanent state of cell-cycle arrest, is emerging as an intrinsic barrier against tumorigenesis and a mechanism contributing to organismal ageing. Unexpected findings now identify multiple secreted inflammatory cytokines, their cognate receptors and positive-feedback loops with corresponding transcription factors, as key mediators of both oncogene-induced and replicative senescence.

引用

页码：887 / 889

页数：4

共 15 条

[11] ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage [J].