What ave surrogate outcome measures and why do they fail in clinical research?

被引:19
作者
Johnston, KC [1 ]
机构
[1] Univ Virginia, Dept Neurol & Hlth Evaluat Sci, Charlottesville, VA USA
关键词
surrogate outcome; clinical trials; stroke; cerebral infarct volume;
D O I
10.1159/000026208
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Surrogate outcome measures have been of interest in clinical research for a long time because of their potential ability to save time and cost. The literature, however, has numerous examples of failed surrogate measures. The definition of a surrogate outcome measure, its consideration in clinical stroke research and some of the potential mechanisms for failure of surrogate measures will be discussed.
引用
收藏
页码:167 / 173
页数:7
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