What ave surrogate outcome measures and why do they fail in clinical research?

被引：19

作者：

Johnston, KC ^{[1
]}

机构：

[1] Univ Virginia, Dept Neurol & Hlth Evaluat Sci, Charlottesville, VA USA

来源：

NEUROEPIDEMIOLOGY | 1999年 / 18卷 / 04期

关键词：

surrogate outcome; clinical trials; stroke; cerebral infarct volume;

D O I：

10.1159/000026208

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Surrogate outcome measures have been of interest in clinical research for a long time because of their potential ability to save time and cost. The literature, however, has numerous examples of failed surrogate measures. The definition of a surrogate outcome measure, its consideration in clinical stroke research and some of the potential mechanisms for failure of surrogate measures will be discussed.

引用

页码：167 / 173

页数：7