Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition

被引：28

作者：

Allen, Naomi E. ^{[1
,2
,3
]}

Appleby, Paul N. ^{[3
]}

Key, Timothy J. ^{[3
]}

Bueno-de-Mesquita, H. B. ^{[4
,5
]}

Ros, Martine M. ^{[4
,6
]}

Kiemeney, Lambertus A. L. M. ^{[6
,7
,8
]}

Tjonneland, Anne ^{[9
]}

Roswall, Nina ^{[9
]}

Overvad, Kim ^{[10
]}

Weikert, Steffen ^{[11
,12
]}

Boeing, Heiner ^{[11
]}

Chang-Claude, Jenny ^{[13
]}

Teucher, Birgit ^{[13
]}

Panico, Salvatore ^{[14
]}

Sacerdote, Carlotta ^{[15
,16
]}

Tumino, Rosario ^{[17
]}

Palli, Domenico ^{[18
]}

Sieri, Sabina ^{[19
]}

Peeters, Petra ^{[20
,21
]}

Ramon Quiros, Jose ^{[22
]}

Jakszyn, Paula ^{[23
]}

Molina-Montes, Esther ^{[24
]}

Chirlaque, Maria-Dolores ^{[25
,26
]}

Ardanaz, Eva ^{[27
]}

Dorronsoro, Miren ^{[28
]}

Khaw, Kay-Tee

Wareham, Nick ^{[29
]}

Ljungberg, Borje ^{[30
]}

Hallmans, Goran ^{[31
]}

Ehrnstrom, Roy ^{[32
]}

Ericson, Ulrika ^{[33
]}

Torhild Gram, Inger ^{[34
]}

Parr, Christine L. ^{[35
]}

Trichopoulou, Antonia ^{[36
,37
]}

Karapetyan, Tina ^{[37
]}

Dilis, Vardis ^{[37
]}

Clavel-Chapelon, Francoise ^{[38
,39
]}

Boutron-Ruault, Marie-Christine ^{[38
,39
]}

Fagherrazzi, Guy ^{[38
,39
]}

Romieu, Isabelle ^{[40
]}

Gunter, Marc J. ^{[21
]}

Riboli, Elio ^{[21
]}

机构：

[1] Univ Oxford, Clin Trial Serv Unit, Oxford OX3 7LF, England

[2] Univ Oxford, Epidemiol Studies Unit, Oxford OX3 7LF, England

[3] Univ Oxford, Canc Epidemiol Unit, Oxford OX3 7LF, England

[4] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[5] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[6] Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol Biostat & HTA, NL-6525 ED Nijmegen, Netherlands

[7] Radboud Univ Nijmegen, Med Ctr, Dept Urol, NL-6525 ED Nijmegen, Netherlands

[8] Comprehens Canc Ctr Netherlands, Utrecht, Netherlands

[9] Danish Canc Soc, Unit Diet Genes & Environm, Copenhagen, Denmark

[10] Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark

[11] German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany

[12] Charite, Dept Urol, D-13353 Berlin, Germany

[13] German Canc Res Ctr, Div Canc Epidemiol, Deutsch Krebsforschungzentrum, Heidelberg, Germany

[14] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[15] Human Genet Fdn, Turin, Italy

[16] CPO Piemonte, Turin, Italy

[17] Civile MP Arezzo Hosp, Canc Registry & Histopathol Unit, Ragusa, Italy

[18] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[19] Fdn IRCCS Ist Nazl Tumori Via Venezian, Nutr Epidemiol Unit, Milan, Italy

[20] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[21] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[22] Hlth & Hlth Care Serv Council, Publ Hlth Directorate, Asturias, Spain

[23] Catalan Inst Oncol, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain

[24] Andalusian Sch Publ Hlth, Granada, Spain

[25] Murcia Reg Hlth Author, Dept Epidemiol, Murcia, Spain

[26] Navarre Publ Hlth Inst, Pamplona, Spain

[27] Basque Reg Hlth Dept, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[28] Univ Cambridge, Dept Publ Hlth & Primacy Care, Cambridge, England

[29] MRC Epidemiol Unit, Cambridge, England

[30] Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden

[31] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[32] Skane Univ Hosp Malm, Dept Pathol, Malmo, Sweden

[33] Lund Univ, Dept Clin Sci Malmo, Malmo, Sweden

[34] Univ Tromso, Inst Community Med, Fac Hlth Sci, Tromso, Norway

[35] Univ Oslo, Inst Basic Med Sci, Dept Biostat, Oslo, Norway

[36] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece

[37] Hellen Hlth Fdn, Athens, Greece

[38] Inst Gustave Roussy, INSERM, Ctr Res Epidemiol & Populat Hlth, U1018, F-94805 Villejuif, France

[39] Paris S Univ, UMRS 1018, Villejuif, France

[40] Int Agcy Res Canc, Nutr & Metab Sect, F-69372 Lyon, France

来源：

INTERNATIONAL JOURNAL OF CANCER | 2013年 / 132卷 / 03期

基金：

英国医学研究理事会;

关键词：

nutrients; diet; bladder cancer; cohort studies; epidemiology; BLADDER-CANCER; FATTY-ACIDS; IGF-I; DIET; ASSOCIATION; METAANALYSIS; CALIBRATION; SUPPLEMENTS; MORTALITY; COUNTRIES;

D O I：

10.1002/ijc.27643

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Previous studies have suggested that dietary factors may be important in the development of bladder cancer. We examined macronutrient intake in relation to risk of urothelial cell carcinoma among 469,339 men and women in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by sex, age at recruitment and centre and further adjusted for smoking status and duration, body mass index and total energy intake. After an average of 11.3 years of follow-up, 1,416 new cases of urothelial cell carcinoma were identified. After allowing for measurement error, a 3% increase in the consumption of energy intake from animal protein was associated with a 15% higher risk (95% confidence interval [CI]: 330%; ptrend = 0.01) and a 2% increase in energy from plant protein intake was associated with a 23% lower risk (95% CI: 367%, ptrend = 0.006). Dietary intake of fat, carbohydrate, fibre or calcium was not associated with risk. These findings suggest that animal and/or plant protein may affect the risk of urothelial cell carcinoma, and examination of these associations in other studies is needed.

引用

页码：635 / 644

页数：10

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