Co-expression of receptor tyrosine kinases in esophageal adenocarcinoma and squamous cell cancer

被引：42

作者：

Gockel, Ines ^{[2
,3
]}

Moehler, Markus ^{[1
,3
]}

Frerichs, Kirsten ^{[2
,3
]}

Drescher, Daniel ^{[2
,3
]}

Trinh, Tran Tong ^{[2
]}

Duenschede, Friedrich ^{[2
]}

Borschitz, Thomas ^{[2
]}

Schimanski, Katrin ^{[3
]}

Biesterfeld, Stefan ^{[4
]}

Herzer, Kerstin ^{[1
]}

Galle, Peter R. ^{[1
]}

Lang, Hauke ^{[2
]}

Junginger, Theodor ^{[2
]}

Schimanski, Carl C. ^{[1
,3
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Dept Internal Med, Med Clin 1, D-55131 Mainz, Germany

[2] Johannes Gutenberg Univ Mainz, Dept Gen & Abdominal Surg, D-55131 Mainz, Germany

[3] Johannes Gutenberg Univ Mainz, Interdisciplinary Translat Oncol Lab, D-55131 Mainz, Germany

[4] Johannes Gutenberg Univ Mainz, Inst Pathol, D-55131 Mainz, Germany

来源：

ONCOLOGY REPORTS | 2008年 / 20卷 / 04期

关键词：

vascular endothelial growth factor receptor; epidermal growth factor receptor; platelet-derived growth factor receptor; esophageal adenocarcinoma; esophageal squamous cell cancer;

D O I：

10.3892/or_00000081

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

This study aimed to define the co-expression pattern of target receptor tyrosine kinases (RTKs) in human esophageal adenocarcinoma and squamous cell cancer. The co-expression pattern of vascular endothelial growth factor receptor (VEGFR)1-3, platelet-derved growth factor receptor (PDGFR)(alpha/beta) and epidermal growth factor receptor 1 (EGFR1) was analyzed by RT-PCR in 50 human esophageal cancers (35 adenocarcinomas and 15 squamous cell cancers). In addition, IHC staining was applied for the confirmation of the expression and analysis of RTK localisation. The adenocarcinoma samples revealed VEGFR1 (97%), VEGFR2 (94%), VEGFR3 (77%), PDGFR alpha (91%), PDGFR beta (85%) and EGFR1 (97%) expression at different intensities. Ninety-four percent of the esophageal adenocarcinomas expressed at least four out of six RTKs. Similarly, squamous cell cancers revealed VEGFR1 (100%), VEGFR2 (100%), VEGFR3 (53%), PDGFRa (100%), PDGFR beta (87%) and EGFR1 (100%) expression at different intensities. All esophageal squamous cell carcinomas expressed at least four out of six RTKs. While VEGFR1-3 and PDGFR alpha and EGFR1 was expressed by tumor cells, PDGFR beta was restricted to stromal cells, which also depicted a PDGFR alpha expression. Our results revealed a high rate of RTK coexpression in esophageal adenocarcinoma and squamous cell cancer and may encourage application of multi-target RTK inhibitors within a multimodal concept as a promising novel approach for innovative treatment strategies.

引用

页码：845 / 850

页数：6

共 28 条

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