Biosynthesis, structure, and function of neuromelanin and its relation to Parkinson's disease: A critical update

被引：43

作者：

dIschia, M

Prota, G

机构：

[1] Dept. of Organ. and Biol. Chemistry, University of Naples Federico II

[2] Dept. of Organ. and Biol. Chemistry, University of Naples Federico II, I-80134 Naples

来源：

PIGMENT CELL RESEARCH | 1997年 / 10卷 / 06期

关键词：

extracutaneous melanins; dopamine; cysteinyldopamine; substantia nigra; neuronal degeneration; oxidative stress;

D O I：

10.1111/j.1600-0749.1997.tb00694.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

No longer dismissed as just a mere curiosity in the family of melanin pigments, neuromelanin is attracting increasing interest as a central constituent of certain populations of dopaminergic neurons in the human substantia nigra, which may hold the key for the understanding of neuron functioning and degeneration in aging and in Parkinson's disease, It is the purpose of this article to provide a concise review of the most significant data on the origin, structure, and functional significance of neuromelanin that accrued over the past few years. It also aims at critically surveying the currently debated views regarding the Pole of such intriguing pigment in the etiology and biochemical pathology of Parkinson's disease.

引用

页码：370 / 376

页数：7

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