EVIDENCE FOR NEUROMELANIN INVOLVEMENT IN MPTP-INDUCED NEUROTOXICITY

被引：99

作者：

DAMATO, RJ

ALEXANDER, GM

SCHWARTZMAN, RJ

KITT, CA

PRICE, DL

SNYDER, SH

机构：

[1] JOHNS HOPKINS MED INST,DEPT NEUROSCI,725 N WOLFE ST,BALTIMORE,MD 21205

[2] JOHNS HOPKINS MED INST,DEPT PHARMACOL & MOLEC SCI,BALTIMORE,MD 21205

[3] JOHNS HOPKINS MED INST,DEPT PSYCHIAT & BEHAV SCI,BALTIMORE,MD 21205

[4] JOHNS HOPKINS MED INST,DEPT PATHOL,BALTIMORE,MD 21205

[5] THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DEPT NEUROL,PHILADELPHIA,PA 19107

来源：

NATURE | 1987年 / 327卷 / 6120期

关键词：

D O I：

10.1038/327324a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：324 / 326

页数：3

共 27 条

[1] SENSITIVE METHOD FOR THE DETERMINATION OF CHLOROQUINE AND ITS METABOLITE DESETHYL-CHLOROQUINE IN HUMAN-PLASMA AND URINE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

BERGQVIST, Y ;

FRISKHOLMBERG, M .

JOURNAL OF CHROMATOGRAPHY, 1980, 221 (01) :119-127

[2] A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].

BURNS, RS ;

CHIUEH, CC ;

MARKEY, SP ;

EBERT, MH ;

JACOBOWITZ, DM ;

KOPIN, IJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550

[3] METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].

CHIBA, K ;

TREVOR, A ;

CASTAGNOLI, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578

[4]

COYLE JT, 1972, BIOCHEM PHARMACOL, V21, P1935, DOI 10.1016/0006-2952(72)90006-8

[5] CHARACTERIZATION OF THE BINDING OF N-METHYL-4-PHENYLPYRIDINE, THE TOXIC METABOLITE OF THE PARKINSONIAN NEUROTOXIN N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE, TO NEUROMELANIN [J].

DAMATO, RJ ;

BENHAM, DF ;

SNYDER, SH .

JOURNAL OF NEUROCHEMISTRY, 1987, 48 (02) :653-658

[6] SELECTIVITY OF THE PARKINSONIAN NEUROTOXIN MPTP - TOXIC METABOLITE MPP+ BINDS TO NEUROMELANIN [J].

DAMATO, RJ ;

LIPMAN, ZP ;

SNYDER, SH .

SCIENCE, 1986, 231 (4741) :987-989

[7] CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS [J].

DAVIS, GC ;

WILLIAMS, AC ;

MARKEY, SP ;

EBERT, MH ;

CAINE, ED ;

REICHERT, CM ;

KOPIN, IJ .

PSYCHIATRY RESEARCH, 1979, 1 (03) :249-254

[8] LYSOSOMOTROPIC AGENTS [J].

DEDUVE, C ;

DEBARSY, T ;

POOLE, B ;

TROUET, A ;

TULKENS, P ;

VANHOOF, F .

BIOCHEMICAL PHARMACOLOGY, 1974, 23 (18) :2495-+

[9] INFLUENCE OF SELECTIVE, REVERSIBLE INHIBITORS OF MONOAMINE-OXIDASE ON THE PROLONGED DEPLETION OF STRIATAL DOPAMINE BY 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE IN MICE [J].

FULLER, RW ;

HEMRICKLUECKE, SK .

LIFE SCIENCES, 1985, 37 (12) :1089-1096

[10]

GRUNDMANN M, 1972, ARCH INT PHARMACOD T, V197, P45

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