SELECTIVITY OF THE PARKINSONIAN NEUROTOXIN MPTP - TOXIC METABOLITE MPP+ BINDS TO NEUROMELANIN

被引：267

作者：

DAMATO, RJ

LIPMAN, ZP

SNYDER, SH

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,725 N WOLFE ST,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,BALTIMORE,MD 21205

来源：

SCIENCE | 1986年 / 231卷 / 4741期

关键词：

D O I：

10.1126/science.3080808

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：987 / 989

页数：3

共 28 条

[1] BJORKLUND A, 1984, HDB CHEM NEUROANATOM, V2, P89
[2] A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
BURNS, RS
CHIUEH, CC
MARKEY, SP
EBERT, MH
JACOBOWITZ, DM
KOPIN, IJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14): : 4546 - 4550
[3] BURNS RS, 1984, CAN J NEUROL SCI, V11, P166
[4] ETIOLOGY OF PARKINSONS-DISEASE
CALNE, DB
LANGSTON, JW
[J]. LANCET, 1983, 2 (8365) : 1457 - 1459
[5] POTENTIAL BIOACTIVATION PATHWAYS FOR THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP)
CASTAGNOLI, N
CHIBA, K
TREVOR, AJ
[J]. LIFE SCIENCES, 1985, 36 (03) : 225 - 230
[6] COTZIAS GC, 1964, FED PROC, V23, P713
[7] NEURONAL PIGMENTS - SPECTROSCOPIC CHARACTERIZATION OF HUMAN-BRAIN MELANIN
DAS, KC
ABRAMSON, MB
KATZMAN, R
[J]. JOURNAL OF NEUROCHEMISTRY, 1978, 30 (03) : 601 - 606
[8] CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS
DAVIS, GC
WILLIAMS, AC
MARKEY, SP
EBERT, MH
CAINE, ED
REICHERT, CM
KOPIN, IJ
[J]. PSYCHIATRY RESEARCH, 1979, 1 (03) : 249 - 254
[9] NEUROCHEMICAL AND HISTOCHEMICAL CHARACTERIZATION OF NEUROTOXIC EFFECTS OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE ON BRAIN CATECHOLAMINE NEURONS IN THE MOUSE
HALLMAN, H
LANGE, J
OLSON, L
STROMBERG, I
JONSSON, G
[J]. JOURNAL OF NEUROCHEMISTRY, 1985, 44 (01) : 117 - 127
[10] HAMBERGER B, 1967, ACTA PHYSIOL SCAND S, V295, P1

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