Effect of 20(S)-ginsenoside Rg3 on streptozotocin-induced experimental type 2 diabetic rats: a urinary metabonomics study by rapid-resolution liquid chromatography/mass spectrometry

被引：59

作者：

Niu, Jun ^{[1
,2
]}

Pi, Zi-Feng ^{[1
]}

Yue, Hao ^{[3
]}

Yang, Hongmei ^{[1
]}

Wang, Yang ^{[3
]}

Yu, Qing ^{[1
,2
]}

Liu, Shu-Ying ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Changchun Ctr Mass Spectrometry, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

[3] Changchun Univ Chinese Med, Jilin Ginseng Acad, Changchun 130117, Peoples R China

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2012年 / 26卷 / 23期

基金：

中国国家自然科学基金;

关键词：

MASS-SPECTROMETRY; PANAX-GINSENG; BILE-ACIDS; METABOLISM; MODEL; MECHANISM; COMPONENT; EXTRACT; TISSUES; AMPK;

D O I：

10.1002/rcm.6392

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

RATIONALE 20(S)-ginsenoside Rg3 is an active component of Panax ginseng. It is known that 20(S)-ginsenoside Rg3 has a protective effect against hyperglycemia, obesity and diabetes in vivo, but the precise mechanisms of these actions have not yet been entirely elucidated. METHODS A urinary metabonomics method based on rapid-resolution liquid chromatography/mass spectrometry (RRLC/MS) was developed to investigate the effect of 20(S)-ginsenoside Rg3 on type 2 diabetic rats. RESULTS With multivariate statistical analysis, a clear separation between type 2 diabetic rats and those treated with 20(S)-ginsenoside Rg3 was achieved. Six potential biomarkers were found and identified. CONCLUSIONS This work shows that the mechanism of the effect of 20(S)-ginsenoside Rg3 on type 2 diabetes may be involved with the regulation of nucleic acid metabolism, energy metabolism and gut flora metabolism. Copyright (C) 2012 John Wiley & Sons, Ltd.

引用

页码：2683 / 2689

页数：7

共 36 条

[1]

Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO

[2]

2-S

[3]

[Anonymous], 2006, DIABETES ATLAS, V3rd

[4]

Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component [J].

Attele, AS ;

Zhou, YP ;

Xie, JT ;

Wu, JA ;

Zhang, L ;

Dey, L ;

Pugh, W ;

Rue, PA ;

Polonsky, KS ;

Yuan, CS .

DIABETES, 2002, 51 (06) :1851-1858

[5]

Ginseng pharmacology - Multiple constituents and multiple actions [J].

Attele, AS ;

Wu, JA ;

Yuan, CS .

BIOCHEMICAL PHARMACOLOGY, 1999, 58 (11) :1685-1693

[6]

BALES JR, 1984, CLIN CHEM, V30, P426

[7]

BENNETT RA, 1981, CANCER RES, V41, P2786

[8]

Effect of mitiglinide on Streptozotocin-induced experimental type 2 diabetic rats: A urinary metabonomics study based on ultra-performance liquid chromatography-tandem mass spectrometry [J].

Cai, Shuang ;

Huo, Taoguang ;

Xu, Jinghua ;

Lu, Xiumei ;

Zheng, Shuning ;

Li, Famei .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2009, 877 (29) :3619-3624

[9]

Metabonomic study of aristolochic acid-induced nephrotoxicity in rats [J].

Chen, MJ ;

Su, MM ;

Zhao, LP ;

Jiang, J ;

Liu, P ;

Cheng, JY ;

Lai, YJ ;

Liu, YM ;

Jia, W .

JOURNAL OF PROTEOME RESEARCH, 2006, 5 (04) :995-1002

[10]

Bile acid regulation of hepatic physiology - III. Bile acids and nuclear receptors [J].

Chiang, JYL .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2003, 284 (03) :G349-G356

← 1 2 3 4 →