Design of scytalone dehydratase inhibitors as rice blast fungicides: Derivatives of norephedrine

被引:26
作者
Basarab, GS
Jordan, DB
Gehret, TC
Schwartz, RS
Wawrzak, Z
机构
[1] DuPont Co Inc, Expt Stn, Wilmington, DE 19880 USA
[2] DuPont Co Inc, Stine Haskell Res Ctr, Newark, DE 19714 USA
关键词
D O I
10.1016/S0960-894X(99)00247-4
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Five X-ray crystal structures of scytalone dehydratase complexed with different inhibitors have delineated conformationally flexible regions of the binding pocket. This information was used for the design and synthesis of a norephedrine-derived cyanoacetamide class of inhibitors leading to potent fungicides. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1613 / 1618
页数:6
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