Design of scytalone dehydratase inhibitors as rice blast fungicides: Derivatives of norephedrine

被引：26

作者：

Basarab, GS

Jordan, DB

Gehret, TC

Schwartz, RS

Wawrzak, Z

机构：

[1] DuPont Co Inc, Expt Stn, Wilmington, DE 19880 USA

[2] DuPont Co Inc, Stine Haskell Res Ctr, Newark, DE 19714 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(99)00247-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five X-ray crystal structures of scytalone dehydratase complexed with different inhibitors have delineated conformationally flexible regions of the binding pocket. This information was used for the design and synthesis of a norephedrine-derived cyanoacetamide class of inhibitors leading to potent fungicides. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：1613 / 1618

页数：6

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