Aging, Immunity, and Cancer

被引：221

作者：

Fulop, Tamas ^{[1
]}

Larbi, Anis ^{[2
]}

Kotb, Rami ^{[3
]}

de Angelis, Flavia ^{[4
]}

Pawelec, Graham ^{[5
]}

机构：

[1] Univ Sherbrooke, Res Ctr Aging, Sherbrooke, PQ J1H 4C4, Canada

[2] Agcy Sci Technol & Res, Singapore Immunol Network SIgN, Singapore, Singapore

[3] Univ Sherbrooke, Fac Med, Dept Med, Div Haematol, Sherbrooke, PQ J1H 4C4, Canada

[4] Univ Sherbrooke, Fac Med, Dept Med, Div Oncol, Sherbrooke, PQ J1H 4C4, Canada

[5] Univ Tubingen, Med Res Ctr, Tubingen, Germany

来源：

DISCOVERY MEDICINE | 2011年 / 11卷 / 61期

基金：

加拿大健康研究院;

关键词：

REGULATORY T-CELLS; DENDRITIC CELLS; CYTOMEGALOVIRUS-INFECTION; LYMPHOCYTE SUBPOPULATIONS; MIR-17-92; CLUSTER; OXIDATIVE STRESS; INNATE IMMUNITY; AGE; IMMUNOSENESCENCE; INFLAMMATION;

D O I：

10.1016/j.coi.2004.01.009

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Age is the most important risk factor for tumorigenesis. More than 60% of new cancers and more than 70% of cancer deaths occur in elderly subjects >65 years. The immune system plays an important role in the battle of the host against cancer development. Deleterious alterations occur to the immune response with aging, termed immunosenescence. It is tempting to speculate that this waning immune response contributes to the higher incidence of cancer, but robust data on this important topic are few and far between. This review is devoted to discussing state of the art knowledge on the relationship between immunosenescence and cancer. Emerging understanding of the aging process at the molecular level is viewed from the perspective of this increased tumorigenesis. We also consider some of the most recent means to intervene in the modulation of immunosenescence to increase the ability of the immune system to fight against tumors. Future research will unravel new aspects of the immune response against tumors which will be modulable to decrease the burden of cancer in elderly individuals. [Discovery Medicine 11(61):537-550, June 2011]

引用

页码：537 / 550

页数：14

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