Hypoglycemic and hypolipidemic effects of Moringa oleifera leaves and their functional chemical constituents

被引：83

作者：

Chen, Gui-Lin ^{[1
,2
,3
]}

Xu, Yong-Bing ^{[1
,2
,3
,4
]}

Wu, Jian-Lin ^{[5
]}

Li, Na ^{[5
]}

Guo, Ming-Quan ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Wuhan Bot Garden, Key Lab Plant Germplasm Enhancement & Specialty A, Wuhan, Peoples R China

[2] Chinese Acad Sci, Sino Africa Joint Res Ctr, Wuhan, Peoples R China

[3] Chinese Acad Sci, Innovat Acad Drug Discovery & Dev, Shanghai, Peoples R China

[4] Grad Univ Chinese Acad Sci, Beijing, Peoples R China

[5] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China

来源：

FOOD CHEMISTRY | 2020年 / 333卷

关键词：

Moringa oleifera; Hyperglycemia; Hyperlipidemia; alpha-glucosidase; Pancreatic lipase; UF-LC/MS; GLUCOSIDASE INHIBITORY-ACTIVITY; ALPHA-GLUCOSIDASE; PANCREATIC LIPASE; INSULIN-RESISTANCE; LEAF EXTRACT; ANTIOXIDANT; FLAVONOIDS; POLYPHENOLS; MECHANISM;

D O I：

10.1016/j.foodchem.2020.127478

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Moringa oleifera Lam. (M. oleifera) leaves have long been consumed as both nutritive vegetable and popular folk medicine for hyperglycemia and hyperlipidemia in Kenya communities. In the current study, in vitro inhibition by M. oleifera leaf extract (MOLE, 90% (v/v) ethanol) of alpha-glucosidase and pancreatic lipase was demonstrated, followed by determination of the effects of MOLE on both glucose consumption and lipid levels (TC, TG, HDL-C and LDL-C) in 3T3-L1 cells. Potential ligands in MOLE were fast screened using affinity ultrafiltration LC-MS, and 14 and 10 components displayed certain binding affinity to alpha-glucosidase and pancreatic lipase, respectively. Docking studies revealed the binding energies and hydrogen bonds between potential ligands and enzymes. This study suggests that M. oleifera leaves may be a promising natural source for the prevention and treatment of hyperglycemia and hyperlipidemia as well as a functional food or other product for health care in the near future.

引用

页数：9

共 40 条

[1]

Moringa oleifera leaf extract ameliorates alloxan-induced diabetes in rats by regeneration of β cells and reduction of pyruvate carboxylase expression [J].