Recent discoveries concerning the tumor - mesenchymal stem cell interactions

被引：106

作者：

Lazennec, Gwendal ^{[1
,2
]}

Lam, Paula Y. P. ^{[3
,4
,5
]}

机构：

[1] CNRS, SYS2DIAG, Cap Delta, 1682 Rue Valsiere, F-34184 Montpellier, France

[2] CNRS, GDR Microenvrionment Tumor Niches 3697, Micronit, France

[3] Natl Canc Ctr, Div Cellular & Mol Res, Singapore, Singapore

[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore 117597, Singapore

[5] Duke NUS Grad Med Sch, Canc & Stem Cells Biol Program, Singapore 169857, Singapore

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2016年 / 1866卷 / 02期

基金：

英国医学研究理事会;

关键词：

Tumor microenvironment; Mesenchymal stem cells; Chemokines; Cytokines; BREAST-CANCER CELLS; MARROW STROMAL CELLS; IN-VITRO; SPONTANEOUS TRANSFORMATION; TRYPTOPHAN DEGRADATION; CONDITIONED MEDIUM; COLORECTAL-CANCER; GASTRIC-CANCER; GROWTH; MIGRATION;

D O I：

10.1016/j.bbcan.2016.10.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Tumor microenvironment plays a crucial role in coordination with cancer cells in the establishment, growth and dissemination of the tumor. Among cells of the microenvironment, mesenchymal stem cells (MSCs) and their ability to evolve into cancer associated fibroblasts (CAFs) have recently generated a major interest in the field. Numerous studies have described the potential pro- or anti-tumorigenic action of MSCs. The goal of this review is to synthesize recent and emerging discoveries concerning the mechanisms by which MSCs can be attracted to tumor sites, how they can generate CAFs and by which way MSCs are able to modulate the growth, response to treatments, angiogenesis, invasion and metastasis of tumors. The understanding of the role of MSCs in tumor development has potential and clinical applications in terms of cancer management. (C) 2016 The Authors. Published by Elsevier B.V.

引用

页码：290 / 299

页数：10

共 100 条

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Human mesenchymal stem cells modulate allogeneic immune cell responses [J].