Local protein synthesis and spine morphogenesis: Fragile X syndrome and beyond

被引：135

作者：

Grossman, Aaron W.

Aldridge, Georgina M.

Weiler, Ivan Jeanne

Greenough, William T.

机构：

[1] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA

[2] Univ Illinois, Grad Program Neurosci, Urbana, IL 61801 USA

[3] Univ Illinois, Med Scholars Program, Urbana, IL 61801 USA

[4] Univ Illinois, Dept Psychol, Urbana, IL 61801 USA

[5] Univ Illinois, Dept Psychiat, Urbana, IL 61801 USA

[6] Univ Illinois, Dept Cell & Struct Biol, Urbana, IL 61801 USA

来源：

JOURNAL OF NEUROSCIENCE | 2006年 / 26卷 / 27期

关键词：

synaptic plasticity; CaMKII; FRMP; Rho GTPases; Fmr1 knock-out mice; synaptogenesis; learning and memory; metabotropic glutamate receptor; Rac1; SHANK-HOMER; dendritic spine; PSD-95;

D O I：

10.1523/JNEUROSCI.1790-06.2006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).

引用

收藏

页码：7151 / 7155

页数：5

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