Lethal action of quinolones against a temperature-sensitive dnaB replication mutant of Escherichia coli

被引：19

作者：

Zhao, XL ^{[1
]}

Malik, M ^{[1
]}

Chan, N ^{[1
]}

Drlica-Wagner, A ^{[1
]}

Wang, JY ^{[1
]}

Li, XY ^{[1
]}

Drlica, K ^{[1
]}

机构：

[1] Publ Hlth Res Inst, Newark, NJ 07103 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 01期

关键词：

D O I：

10.1128/AAC.50.1.362-364.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Inhibition of DNA replication in an Escherichia coli dnaB-22 mutant failed to block quinolone-mediated lethality. Inhibition of protein synthesis by chloramphenicol inhibited nalidixic acid lethality and, to a lesser extent, ciprofloxacin lethality in both dnaB-22 and wild-type cells. Thus, major features of quinolone-mediated lethality do not depend on ongoing replication.

引用

页码：362 / 364

页数：3

共 26 条

[21]

TSAO YP, 1993, CANCER RES, V53, P5908

[22] PHAGE-P1 MUTANTS WITH ALTERED TRANSDUCING ABILITIES FOR ESCHERICHIA-COLI [J].

WALL, JD ;

HARRIMAN, PD .

VIROLOGY, 1974, 59 (02) :532-544

[23] The complex of DNA gyrase and quinolone drugs on DNA forms a barrier to the T7 DNA polymerase replication complex [J].

Wentzell, LM ;

Maxwell, A .

JOURNAL OF MOLECULAR BIOLOGY, 2000, 304 (05) :779-791

[24] THE COMPLEX OF DNA GYRASE AND QUINOLONE DRUGS WITH DNA FORMS A BARRIER TO TRANSCRIPTION BY RNA-POLYMERASE [J].

WILLMOTT, CJR ;

CRITCHLOW, SE ;

EPERON, IC ;

MAXWELL, A .

JOURNAL OF MOLECULAR BIOLOGY, 1994, 242 (04) :351-363

[25] A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases [J].

Yang, SW ;

Burgin, AB ;

Huizenga, BN ;

Robertson, CA ;

Yao, KC ;

Nash, HA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (21) :11534-11539

[26] DNA topoisomerase targets of the fluoroquinolones: A strategy for avoiding bacterial resistance [J].

Zhao, XL ;

Xu, C ;

Domagala, J ;

Drlica, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) :13991-13996

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