Pore formation coupled to ion transport through lipid membranes as induced by transmembrane ionic charge imbalance: Atomistic molecular dynamics study

被引:173
作者
Gurtovenko, AA [1 ]
Vattulainen, I
机构
[1] Aalto Univ, Phys Lab, POB 1100, FI-02015 Helsinki, Finland
[2] Aalto Univ, Helsinki Univ Technol, Helsinki Inst Phys, FI-02015 Helsinki, Finland
[3] Univ So Denmark, Dept Phys, Memphys Ctr Biomembrane Phys, DK-5230 Odense, Denmark
关键词
D O I
10.1021/ja053129n
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We have employed atomic-scale molecular dynamics simulations to address ion transport through transient water pores in phospholipid membranes. The formation of a water pore is induced by a transmembrane ionic charge imbalance, which gives rise to a significant potential difference across the membrane. The subsequent transport of ions through the pore discharges the transmembrane potential and makes the water pore metastable, leading eventually to its sealing. The findings highlight the importance of ionic charge fluctuations in spontaneous pore formation and their role in ion leakage through protein-free lipid membranes. Copyright © 2005 American Chemical Society.
引用
收藏
页码:17570 / 17571
页数:2
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