Polymorphism and chromosomal localization of the GI-form of human glutathione peroxidase (GPX2) on 14q24.1 by in situ hybridization

被引：36

作者：

Chu, FF

DeSilva, HAR

Esworthy, RS

Boteva, KK

Walters, CE

Roses, A

Rao, PN

Pettenati, MJ

机构：

[1] CITY HOPE NATL MED CTR,DEPT MED ONCOL & THERAPEUT RES,DUARTE,CA 91010

[2] MARIE CURIE RES INST,OXTED RH8 0TL,SURREY,ENGLAND

[3] DUKE UNIV,MED CTR,JOSEPH & KATHLEEN BRYAN ALZHEIMERS DIS RES CTR,DIV NEUROL,DURHAM,NC 27710

[4] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PEDIAT,MED GENET SECT,WINSTON SALEM,NC 27157

来源：

GENOMICS | 1996年 / 32卷 / 02期

关键词：

D O I：

10.1006/geno.1996.0115

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have isolated a 3.3-kb DNA containing the two exons and a 2.6-kb intron of the human GPX2 gene, This gene encodes the intestinal isoenzyme of glutathione peroxidase, GSHPx-GI, Consistent signals were detected at 14q24.1 when this DNA was used as a probe for fluorescence in situ hybridization on metaphase chromosomes, Based on either single-stranded conformation polymorphism or sequencing analysis, two sites containing DNA polymorphism were found in the intron: the 5' end had a single A/T alteration, and the 3' end had a microsatellite of TC repeats. (C) 1996 Academic Press, Inc.

引用

页码：272 / 276

页数：5

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