Effects of alveolar macrophage depletion on liposomal vaccine protection against respiratory syncytial virus (RSV)

被引:30
作者
Benoit, A.
Huang, Y.
Proctor, J.
Rowden, G.
Anderson, R. [1 ]
机构
[1] Dalhousie Univ, Dept Microbiol & Immunol, Halifax, NS B3H 1X5, Canada
[2] Dalhousie Univ, Dept Pathol, Halifax, NS B3H 1X5, Canada
[3] Dalhousie Univ, Dept Pediat, Halifax, NS B3H 1X5, Canada
关键词
inflammation in RSV disease; respiratory syncytial viral G protein vaccine; vaccine-enhanced RSV disease;
D O I
10.1111/j.1365-2249.2006.03114.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Little is known about the identities and roles of antigen-presenting cells upon exposure to antigens of respiratory syncytial virus (RSV). Here, we focused on elucidating the importance of alveolar macrophages in conferring protective immunity in mice administered a liposome-encapsulated recombinant fragment of the RSV G protein. Mice were depleted of alveolar macrophages by intranasal inoculation of liposome-encapsulated dichloromethylenediphosphonic acid (DMDP). Mice depleted of alveolar macrophages prior to immunization developed reduced levels of serum RSV-neutralizing antibody and showed dramatically impaired protection against RSV challenge. The severity of interstitial inflammation was also markedly reduced in macrophage-depleted mice. In conclusion, this study demonstrates a pivotal role for alveolar macrophages during exposure to liposome-encapsulated RSV antigen in initiating both protective and histopathological responses against RSV.
引用
收藏
页码:147 / 154
页数:8
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