A rapid microwave protocol for Heck vinylation of aryl chlorides under air

被引：27

作者：

Datta, Gopal K. ^{[1
]}

Vallin, Karl S. A. ^{[1
]}

Larhed, Mats ^{[1
]}

机构：

[1] Uppsala Univ, Dept Organ Pharmaceut Chem, Biomed Ctr, Uppsala, Sweden

来源：

MOLECULAR DIVERSITY | 2003年 / 7卷 / 2-4期

基金：

瑞典研究理事会;

关键词：

aryl chloride; Heck reaction; ionic liquid; microwave heating; palladium catalysis;

D O I：

10.1023/B:MODI.0000006798.53091.a2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In modern high-throughput chemistry, the overall workflow is a crucial factor and much work is devoted to speeding up the process of chemistry development. Since automated microwave-based synthesizers are known to streamline the compound production and to accelerate slow organic transformations, this technology was implemented for Heck reactions with sluggish aryl chlorides. Furthermore, homogeneous palladium-catalyzed Heck vinylations of aryl chlorides can be performed under air under optimized conditions. Based on this finding, controlled microwave heating was utilized to accelerate model reactions down to 30 min employing a mixture of ionic liquid and 1,4-dioxane as solvent.

引用

页码：107 / 114

页数：8

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