Novel 5-vinyl pyrimidine nucleosides with potent anti-hepatitis B virus activity

被引：9

作者：

Kumar, R ^{[1
]}

Tyrrell, DLJ ^{[1
]}

机构：

[1] Univ Alberta, Fac Med, Dept Med Microbiol & Immunol, Edmonton, AB T6G 2H7, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 22期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0960-894X(01)00589-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Synthesis and antiviral activities of novel N-1 alkyl substituted pyrimidines, 1-[(2-hydroxyethoxy)methyl]-5-vinyluracil (5), 1-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]-5-vinyluracil (6), and 1-[4-hydroxy-3-(hydroxymethyl)-1-butyl]-5-vinyluracil (7) are reported. Compounds 6 and 7 were potent inhibitors of DHBV in cell culture, in contrast all of the compounds described were devoid of activity against TK+ HSV-1 and TK- HSV-1. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：2917 / 2920

页数：4

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