Synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol analogs incorporating natural amino acids

被引：40

作者：

Wang, Peng ^{[1
,2
]}

Bi, Xiu-Li ^{[3
]}

Xu, Jing ^{[1
]}

Yuan, Hao-Nan ^{[1
,2
]}

Piao, Hu-Ri ^{[2
]}

Zhao, Yu-Qing ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[2] Yanbian Univ, Coll Pharm, Minist Educ, Key Lab Nat Resources Changbai Mt & Funct Mol, Yanji 133002, Peoples R China

[3] Liaoning Univ, Sch Life Sci, Shenyang 110036, Peoples R China

来源：

STEROIDS | 2013年 / 78卷 / 02期

基金：

美国国家科学基金会;

关键词：

25-OH-PPD derivatives; Amino acids; Anti-tumor activity; MTT; INTESTINAL BACTERIAL METABOLITE; PROSTATE-CANCER; PANAX-GINSENG; RAT PLASMA; IN-VITRO; PRODUCT; CELLS; GINSENOSIDES; SAPONINS; THERAPY;

D O I：

10.1016/j.steroids.2012.09.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

In the current study, derivatives of 25-hydroxyprotopanaxadiol (25-OH-PPD) were prepared and their in vitro anti-tumor activities were tested on six different human tumor cell lines by standard MET assay. The results showed that combining an ester group combined with the presence of an amino acid moiety led to a 10-fold improved anti-tumor activity. Compound 1c exhibited the best anti-tumor activity in the in vitro assays. Compounds 2c, 3c, 4c, 5c, 6c and 8b showed better anti-tumor activities compared to the parent compound 25-OH-PPD. The current results may provide useful data for researching and developing new anti-cancer agents. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：203 / 209

页数：7

共 21 条

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Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng [J].