Microwave-promoted rhodium-catalyzed arylation of heterocycles through C-H bond activation

被引：126

作者：

Lewis, JC

Wu, JY

Bergman, RG ^{[1
]}

Ellman, JA

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Chem Sci, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 10期

关键词：

arylation; C-H activation; heterocycles; phosphane ligands; rhodium;

D O I：

10.1002/anie.200504289

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Performance-enhancing ligands: Two new bridged bicyclic phosphines 1a,b based on the "phoban" skeleton (see structures of their naphth-2-ylmethyl bromide salts; P yellow, Br brown, C white) are central to a practical catalytic method for the direct arylation of a variety of nitrogen heterocycles using aryl bromides. Broad functional-group tolerance was observed, and the use of microwave radiation allowed for short reaction times. (Chemical Equation Presented) © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：1589 / 1591

页数：3

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