Voltage-gated potassium channels: from hyperexcitability to excitement

被引：147

作者：

Pongs, O ^{[1
]}

机构：

[1] Inst Neurale Signalverarbeitung, ZMNH, D-20246 Hamburg, Germany

来源：

FEBS LETTERS | 1999年 / 452卷 / 1-2期

关键词：

voltage-activated potassium channel; action-potential; hyperexcitability; hearing loss;

D O I：

10.1016/S0014-5793(99)00535-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The superfamily of voltage-activated potassium channels may express structurally and functionally diverse voltage-activated potassium channels in the nervous system. The roles of some voltage-activated potassium channel types, e.g. rapidly inactivating (transiently active type) channels and muscarine sensitive muscarine sensitive channels, are beginning to be understood. They may significantly influence dendritic action-potential back-propagation, signal to noise ratios in presynaptic excitability or the responsiveness of a neuron to synaptic input. Inherited disorders related to changes in excitability (episodic ataxia, epilepsy, heart arrhythmia) or to defects in sensory perception (hearing loss) have been associated with mutations in a few voltage-activated potassium channel genes. Most likely, more voltage-activated potassium channel genes will be linked to related disorders in the near future. (C) 1999 Federation of European Biochemical Societies.

引用

页码：31 / 35

页数：5

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