Identification of kinetic parameters in multidimensional crystallization processes

被引:64
作者
Gunawan, R [1 ]
Ma, DL [1 ]
Fujiwara, M [1 ]
Braatz, RD [1 ]
机构
[1] Univ Illinois, Urbana, IL 61801 USA
来源
INTERNATIONAL JOURNAL OF MODERN PHYSICS B | 2002年 / 16卷 / 1-2期
关键词
D O I
10.1142/S0217979202009883
中图分类号
O59 [应用物理学];
学科分类号
摘要
Advances in sensor technology and increased competition in the pharmaceutical industry have generated significant interest in the identification of models for the solution formation of crystals with multiple characteristic dimensions. A procedure is proposed that uses a small number of batch experiments to identify the kinetic parameters for multidimensional crystallization processes. The parameters are estimated simultaneously from the on-line measurement of infrared spectra and from cross-moments of the crystal size distribution. The identification procedure maximizes the informativeness of the data produced by each experiment, produces an estimate of the accuracy of the kinetic parameters, and allows the consideration of competing hypotheses for characterizing the crystallization kinetics. The parameter identification strategy is applied to the batch crystallization of potassium dihydrogen phosphate, which forms two-dimensional crystals from solution. To the best of the authors' knowledge, this is the first time that the kinetic parameters for a multidimensional crystallization process are identified from a small number of batch experiments.
引用
收藏
页码:367 / 374
页数:8
相关论文
共 16 条
[1]  
Bard Y., 1974, Nonlinear Parameter Estimation
[2]  
BRAATZ RD, 2001, IN PRESS CHEM PROCES, V6
[3]  
BRAATZ RD, 1995, CONTROL HDB, P215
[4]   Optimal model-based experimental design in batch crystallization [J].
Chung, SH ;
Ma, DL ;
Braatz, RD .
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 2000, 50 (01) :83-90
[5]   ATR FTIR spectroscopy for in situ measurement of supersaturation [J].
Dunuwila, DD ;
Berglund, KA .
JOURNAL OF CRYSTAL GROWTH, 1997, 179 (1-2) :185-193
[6]   Worst-case analysis of finite-time control policies [J].
Ma, DL ;
Braatz, RD .
IEEE TRANSACTIONS ON CONTROL SYSTEMS TECHNOLOGY, 2001, 9 (05) :766-774
[7]   Worst-case performance analysis of optimal batch control trajectories [J].
Ma, DL ;
Chung, SH ;
Braatz, RD .
AICHE JOURNAL, 1999, 45 (07) :1469-1476
[8]   Batch crystallization of a photochemical: Modeling, control, and filtration [J].
Matthews, HB ;
Rawlings, JB .
AICHE JOURNAL, 1998, 44 (05) :1119-1127
[9]  
MILLER SM, 1993, THESIS U TEXAS AUSTI
[10]  
Ottens E. P. K., 1972, Journal of Crystal Growth, V13-14, P500, DOI 10.1016/0022-0248(72)90288-6