In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis

被引：39

作者：

Hoeben, BJ

Burgess, DS

McConville, JT

Najvar, LK

Talbert, RL

Peters, JI

Wiederhold, NP

Frei, BL

Graybill, JR

Bocanegra, R

Overhoff, KA

Sinswat, P

Johnston, KP

Williams, RO

机构：

[1] Univ Texas, Hlth Sci Ctr, Clin Pharm Programs, San Antonio, TX 78229 USA

[2] Univ Texas, Coll Pharm, Austin, TX 78712 USA

[3] Univ Texas, Coll Engn, Austin, TX 78712 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 04期

关键词：

D O I：

10.1128/AAC.50.4.1552-1554.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure.

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页码：1552 / 1554

页数：3

相关论文

共 23 条

[1] In vitro susceptibilities of Aspergillus species to voriconazole, itraconazole, and amphotericin B [J].

Abraham, OC ;

Manavathu, EK ;

Cutright, JL ;

Chandrasekar, PH .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1999, 33 (01) :7-11

[2] PROPHYLACTIC EFFICACY OF AEROSOLIZED LIPOSOMAL (AMBISOME) AND NON-LIPOSOMAL (FUNGIZONE) AMPHOTERICIN-B IN MURINE PULMONARY ASPERGILLOSIS [J].

ALLEN, SD ;

SORENSEN, KN ;

NEJDL, MJ ;

DURRANT, C ;

PROFFIT, RT .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1994, 34 (06) :1001-1013

[3] Rapid dissolution of high potency itraconazole particles produced by evaporative precipitation into aqueous solution [J].

Chen, X ;

Benhayoune, Z ;

Williams, RO ;

Johnston, KP .

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2004, 14 (04) :299-304

[4] A survey of anti-fungal management in lung transplantation [J].

Dummer, JS ;

Lazariashvilli, N ;

Barnes, J ;

Ninan, M ;

Milstone, AP .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2004, 23 (12) :1376-1381

[5] Recent advances in pulmonary drug delivery using large, porous inhaled particles [J].

Edwards, DA ;

Ben-Jebria, A ;

Langer, R .

JOURNAL OF APPLIED PHYSIOLOGY, 1998, 85 (02) :379-385

[6] Efficacy of nebulized liposomal amphotericin B in treatment of experimental pulmonary aspergillosis [J].

Gavaldà, J ;

Martín, MT ;

López, P ;

Gomis, X ;

Ramírez, JL ;

Rodríguez, D ;

Len, O ;

Puigfel, Y ;

Ruíz, I ;

Pahissa, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (07) :3028-3030

[7] Rapid and sensitive high performance liquid chromatographic method for the determination of itraconazole and its hydroxy-metabolite in human serum [J].

Gubbins, PO ;

Gurley, BJ ;

Bowman, J .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1998, 16 (06) :1005-1012

[8] Nanoparticle engineering processes for enhancing the dissolution rates of poorly water soluble drugs [J].

Hu, JH ;

Johnston, KP ;

Williams, RO .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2004, 30 (03) :233-245

[9] In vitro pharmacodynamics of amphotericin B, itraconazole, and voriconazole against Aspergillus, Fusarium, and Scedosporium spp. [J].

Lewis, RE ;

Wiederhold, NP ;

Klepser, ME .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (03) :945-951

[10] Ltraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplants [J].

Marr, KA ;

Crippa, F ;

Leisenring, W ;

Hoyle, M ;

Boeckh, M ;

Balajee, SA ;

Nichols, WG ;

Musher, B ;

Corey, L .

BLOOD, 2004, 103 (04) :1527-1533