A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers

被引：39

作者：

Allen, Aideen C. ^{[1
]}

Kelly, Siobhan ^{[2
]}

Basdeo, Sharee A. ^{[1
]}

Kinsella, Katie ^{[2
]}

Mulready, Keith J. ^{[4
]}

Mills, Kingston H. G. ^{[1
]}

Tubridy, Niall ^{[2
]}

Walsh, Cathal ^{[3
]}

Brady, Jennifer J. ^{[4
]}

Hutchinson, Michael ^{[2
]}

Fletcher, Jean M. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Trinity Biomed Sci Inst, Sch Biochem & Immunol, Dublin 2, Ireland

[2] St Vincents Univ Hosp, Dept Neurol, Dublin, Ireland

[3] Trinity Coll Dublin, Dept Stat, Dublin, Ireland

[4] Mater Misericordiae Univ Hosp, Dept Biochem & Diagnost Endocrinol, Dublin, Ireland

来源：

MULTIPLE SCLEROSIS JOURNAL | 2012年 / 18卷 / 12期

基金：

爱尔兰科学基金会;

关键词：

disease modifying therapies; immunology; multiple sclerosis; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MULTIPLE-SCLEROSIS;

D O I：

10.1177/1352458512442992

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Although vitamin D deficiency is considered an environmental factor in multiple sclerosis (MS), the immunological and clinical effects of vitamin D supplementation remain unclear. We performed a pilot study of the immunomodulatory effects of vitamin D in healthy individuals (n=4), who took 5000-10,000 IU/day of vitamin D over 15 weeks. After 15 weeks of vitamin D supplementation, serum 25(OH) vitamin D levels rose significantly from baseline, with a corresponding increase in IL-10 production by peripheral blood mononuclear cells and a reduced frequency of Th17 cells. These data provide a strong rationale for randomised trials to assess the clinical effects of vitamin D supplementation in MS.

引用

页码：1797 / 1800

页数：4

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