Vitamin D and multiple sclerosis

被引：398

作者：

Ascherio, Alberto ^{[1
,2
,3
,4
]}

Munger, Kassandra L. ^{[1
]}

Simon, K. Claire ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Med, Channing Lab, Boston, MA USA

[4] Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

LANCET NEUROLOGY | 2010年 / 9卷 / 06期

关键词：

D-RECEPTOR GENE; D-BINDING PROTEIN; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; 25-HYDROXYVITAMIN D CONCENTRATIONS; RESPIRATORY-TRACT INFECTION; ENVIRONMENTAL SUN EXPOSURE; RESONANCE-IMAGING LESIONS; UNITED-STATES VETERANS; D-ENDOCRINE SYSTEM;

D O I：

10.1016/S1474-4422(10)70086-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The hypothesis that adequate vitamin D nutrition can contribute to the prevention of multiple sclerosis (MS) was originally proposed to explain the geographical distribution of MS, but only recently has the relation between various measures of vitamin D (eg, sun exposure, dietary sources, and serum concentrations of 25-hydroxyvitamin D) and risk of developing MS been rigorously investigated. Overall, the results of these studies support a protective effect of vitamin D, but there are uncertainties and many unanswered questions, including how vitamin D exerts a protective effect, how genetic variations modify the effect, and whether vitamin D can influence the course of MS progression.

引用

页码：599 / 612

页数：14

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